Results of the study of the microbial spectrum in children with autism spectrum disorders associated with genetic deficiency of the folate cycle
Keywords:
immunodiagnostics, immunotherapy, neuropsychiatric disorders, children, diagnostics, therapySynopsis
Evidence from a number of recent independent meta-analyses and systematic reviews of randomized controlled trials, published in peer-reviewed medical journals indexed in the PubMed (MEDLINE) abstract bibliographic electronic database, indicates that genetic deficiency of the folate cycle (GDFC) is associated with the clinical phenotype of autism spectrum disorders (ASD) in children. Results of a meta-analysis of randomized controlled trials by B. Q. Guo et al. in 2020, which included 31 trials involving 3304 children, including 1641 patients with ASD, without genetic clarification of the diagnosis, demonstrated that hyperhomocysteinemia, a phenomenon specific to GDFC, is associated with ASD and is a class feature of such children (Hedges's g = 0.56; 95 % CI = 0.36–0.76, p < 0.001). N. S. Mohammad et al., using the ANN (artificial neural network) model in a controlled clinical study involving 138 children with ASD and 138 healthy individuals, showed that the determination of pathogenic polymorphic variants of the genes GCPII C1561T, SHMT1 C1420T, MTHFR C677T, MTR A2756G, and MTRR A66G for diagnostic purposes allows determining the risk of developing ASD in a carrier with an accuracy of 63.8 %. These data allow us to consider GDFC as the main factor in the genetic predisposition to the development of ASD in children.
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May 19, 2025
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Copyright (c) 2025 Dmytro Maltsev
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Results of the study of the microbial spectrum in children with autism spectrum disorders associated with genetic deficiency of the folate cycle. (2025). In D. Maltsev, IMMUNODIAGNOSTICS AND IMMUNOTHERAPY OF NEUROPSYCHIATRIC DISORDERS IN CHILDREN (pp. 51–64). Kharkiv: TECHNOLOGY CENTER PC. https://doi.org/10.15587/978-617-8360-21-4.ch4
