Results of the assessment of immune status in children with ASD: immunodeficiency associated with genetic deficiency of the folate cycle
Keywords:
Immunodiagnostics, immunotherapy, neuropsychiatric disorders, children, diagnostics, therapyAbstract
The results of the last 5 meta-analyses of randomized controlled clinical trials indicate an association between genetically determined deficiency of folate cycle enzyme (GDFC) and autism spectrum disorders (ASD) in children, however, the mechanism of this relationship, as well as the association with additional clinical manifestations of a broad disease phenotype, has not yet been fully explained. Since there are frequent reports of the association of ASD with immunodeficiency diseases and signs of immune dysregulation, and immune-dependent mechanisms of CNS damage in children with ASD have been described, including opportunistic infections, cerebral autoimmunity, and intracerebral inflammation, there is reason to assume that impaired immune status is a key link in the pathogenesis of ASD in children with GDFC.
Indeed, there is now accumulating evidence that the immune system plays an important role in brain development, participating in the regulation of neuronal proliferation and synapse formation, as well as influencing neuroplasticity processes, so disruption of its functioning may be important in the formation of encephalopathy in children with ASD.
IMMUNODIAGNOSTICS AND IMMUNOTHERAPY OF NEUROPSYCHIATRIC DISORDERS IN CHILDREN
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Pages
30-50
Published
May 19, 2025
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Copyright (c) 2025 Dmytro Maltsev
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Details about the available publication format: PDF
PDF
ISBN-13 (15)
978-617-8360-21-4
How to Cite
Results of the assessment of immune status in children with ASD: immunodeficiency associated with genetic deficiency of the folate cycle. (2025). In D. Maltsev, IMMUNODIAGNOSTICS AND IMMUNOTHERAPY OF NEUROPSYCHIATRIC DISORDERS IN CHILDREN (pp. 30–50). Kharkiv: TECHNOLOGY CENTER PC. https://doi.org/10.15587/978-617-8360-21-4.ch3
