Efficacy of combined use of transfer factors based on colostrum immune extract in NK and NKT cell deficiency in children with autism spectrum disorders associated with genetic deficiency of the folate cycle
Keywords:
Immunodiagnostics, immunotherapy, neuropsychiatric disorders, children, diagnostics, therapyAbstract
Recent decades of research have shown that immunodeficiency and related immune dysregulation are important components in the pathogenesis of multisystemic damage in children with autism spectrum disorders (ASD). Data from 5 meta-analyses and systematic reviews of randomized controlled trials supporting the association of ASD and genetic deficiency of the folate cycle (GDFC) shed light on key factors in the genetic predisposition to the development of severe neuropsychiatric syndromes in children. The results of the last 3 systematic reviews of controlled clinical trials have characterized the spectrum of immunological disorders characteristic of children with ASD, one of the main components of which is the deficiency of natural killer (NK) cells, natural killer T lymphocytes (NKT) and, conversely, an abnormally increased number of CD3 + T lymphocytes in the peripheral blood.
Immune system disorders shed light on the origin of a number of immune-dependent clinical manifestations (allergic, autoimmune, immunoinflammatory, etc.) characteristic of children with ASD, which cannot be explained solely by the existing mental dysfunction.
Correction of immune disorders in children with ASD appears to be a promising tool not only for restoring immune resistance to microorganisms, but also for preventing the development of numerous immune-dependent complications that affect both the CNS and other organs and systems of the child's body.
IMMUNODIAGNOSTICS AND IMMUNOTHERAPY OF NEUROPSYCHIATRIC DISORDERS IN CHILDREN
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