Efficacy of infliximab in autism spectrum disorders in children associated with genetic deficiency of the folate cycle
Keywords:
Immunodiagnostics, immunotherapy, neuropsychiatric disorders, children, diagnostics, therapyAbstract
The notion of systemic inflammation in autism spectrum disorders in children has been established. A recent meta-analysis of randomized controlled trials published in 2019, which included a systematic review of 25 case-control studies, suggests an association between genetic deficiency of the folate cycle and autism spectrum disorders in children. This evidence is consistent with an earlier meta-analysis of randomized controlled trials from 2013, which included data from 8 studies.
The encephalopathy that develops in children with genetic deficiency of the folate cycle and manifests as autism spectrum disorders is associated with oxidative stress. The reason for the latter can be seen in the suppression of the immune system with the development of a special form of immunodeficiency, which is based on the deficiency of natural killers, natural killer T lymphocytes and CD8 + cytotoxic T cells. Immunodeficiency mediates all three known mechanisms of brain damage in children with genetic deficiency of the folate cycle, namely the development of opportunistic infections [2, 15], autoimmune reactions against neuronal antigens and manifestations of systemic inflammation, which is based on the phenomenon of hypercytokinemia.
IMMUNODIAGNOSTICS AND IMMUNOTHERAPY OF NEUROPSYCHIATRIC DISORDERS IN CHILDREN
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